Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

Bacterial vaginosis (BV) is typically caused by a shift in the vaginal microbiota from a Lactobacillus-dominant community to one colonised by strains of Gardenerella vaginalis and treatment with the antibiotic metronidazole (MNZ) often results in failure and recurrence. Here, the authors use modelli...

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Bibliographic Details
Main Authors: Christina Y. Lee, Ryan K. Cheu, Melissa M. Lemke, Andrew T. Gustin, Michael T. France, Benjamin Hampel, Andrea R. Thurman, Gustavo F. Doncel, Jacques Ravel, Nichole R. Klatt, Kelly B. Arnold
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19880-w

Internet

https://doi.org/10.1038/s41467-020-19880-w

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