Multipurpose Prevention Technologies: Biomedical Tools to Prevent HIV-1, HSV-2, and Unintended Pregnancies

by Andrea Ries Thurman, Meredith R. Clark, Gustavo F. Doncel
Published 2011-01-01

Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention

by Meredith R. Clark, M. Melissa Peet, Sarah Davis, Gustavo F. Doncel, David R. Friend
Published 2014-12-01

Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant tech...

by Oluwatosin E Adedipe, Terry A Jacot, Andrea R Thurman, Gustavo F Doncel, Meredith R Clark
Published 2018-01-01

Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice

by Maimoona S. Bhutta, Oren Shechter, Elisa S. Gallo, Stephen D. Martin, Esther Jones, Gustavo F. Doncel, Ronen Borenstein
Published 2021-01-01

Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical Tissues.

by Christiane Rollenhagen, Sherrill L Macura, Melissa J Lathrop, Todd A Mackenzie, Gustavo F Doncel, Susana N Asin
Published 2015-01-01

Development of a composite measure of product adherence, protocol compliance, and semen exposure using DNA and protein biomarkers for topical HIV prevention studies.

by Terry A Jacot, Ashley Nelson, Andrea Thurman, Angela D M Kashuba, David F Archer, Gustavo F Doncel
Published 2014-01-01

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV

by Ashana Puri, Sonalika A. Bhattaccharjee, Wei Zhang, Meredith Clark, Onkar N. Singh, Gustavo F. Doncel, Ajay K. Banga
Published 2019-04-01

Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety.

by Theodore J Segarra, Esra Fakioglu, Natalia Cheshenko, Sarah S Wilson, Pedro M M Mesquita, Gustavo F Doncel, Betsy C Herold
Published 2011-01-01

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings.

by Andrea Ries Thurman, Jill L Schwartz, Jacques Ravel, Pawel Gajer, Mark A Marzinke, Nazita Yousefieh, Sharon M Anderson, Gustavo F Doncel
Published 2019-01-01

Topical Inserts: A Versatile Delivery Form for HIV Prevention

by M. Melissa Peet, Vivek Agrahari, Sharon M. Anderson, Homaira Hanif, Onkar N. Singh, Andrea R. Thurman, Gustavo F. Doncel, Meredith R. Clark
Published 2019-08-01

Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of...

by Irina A Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S Jackson, Titilayo Fashemi, Hidemi S Yamamoto, Robert Settlage, Raina N Fichorova, Gustavo F Doncel
Published 2015-01-01

Adaptation and validation of simple tools to screen and monitor for oral PrEP adherence.

by Seth Zissette, Elizabeth E Tolley, Andres Martinez, Homaira Hanif, Katherine Gill, Nelly Mugo, Laura Myers, Ednar Casmir, Menna Duyver, Kenneth Ngure, Gustavo F Doncel
Published 2021-01-01

Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies

by Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman, Gustavo F. Doncel
Published 2018-11-01

Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age.

by Raina N Fichorova, Charles S Morrison, Pai-Lien Chen, Hidemi S Yamamoto, Yashini Govender, Damilola Junaid, Stanthia Ryan, Cynthia Kwok, Tsungai Chipato, Robert A Salata, Gustavo F Doncel
Published 2020-01-01

Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

by Sharon M. Anderson, Andrea R. Thurman, Neelima Chandra, Suzanne S. Jackson, Susana Asin, Christiane Rollenhagen, Mimi Ghosh, Jason Daniels, Nikolas C. Vann, Meredith R. Clark, Gustavo F. Doncel
Published 2020-10-01

Application of a composite measure of product adherence, protocol compliance, and semen exposure to a phase III microbicide HIV prevention trial

by Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Tina Cunningham, Susan Ju, Jill L. Schwartz, Sinead Delany-Moretlwe, Andrea R. Thurman, Gustavo F. Doncel
Published 2021-09-01

Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

by Christina Y. Lee, Ryan K. Cheu, Melissa M. Lemke, Andrew T. Gustin, Michael T. France, Benjamin Hampel, Andrea R. Thurman, Gustavo F. Doncel, Jacques Ravel, Nichole R. Klatt, Kelly B. Arnold
Published 2020-12-01

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women.

by Andrea Ries Thurman, Jill L Schwartz, Vivian Brache, Meredith R Clark, Timothy McCormick, Neelima Chandra, Mark A Marzinke, Frank Z Stanczyk, Charlene S Dezzutti, Sharon L Hillier, Betsy C Herold, Raina Fichorova, Susana N Asin, Christiane Rollenhagen, Debra Weiner, Patrick Kiser, Gustavo F Doncel
Published 2018-01-01

Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomized Controlled...

by Andrea R. Thurman, MD, Jill L. Schwartz, MD, Mackenzie L. Cottrell, PharmD, Vivian Brache, Lic, Beatrice A. Chen, MD, MPH, Leila Cochón, Lic, Susan Ju, BA, Ian McGowan, MD PhD, James F. Rooney, MD, Scott McCallister, MD, Gustavo F. Doncel, MD PhD
Published 2021-06-01