27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, in ER+ breast cancer patients, 27HC content in...

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Bibliographic Details
Main Authors: Qian Wu, Tomonori Ishikawa, Rosa Sirianni, Hao Tang, Jeffrey G. McDonald, Ivan S. Yuhanna, Bonne Thompson, Luc Girard, Chieko Mineo, Rolf A. Brekken, Michihisa Umetani, David M. Euhus, Yang Xie, Philip W. Shaul
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005755

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http://www.sciencedirect.com/science/article/pii/S2211124713005755

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