Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

Abstract RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-inflammatory cytokines. After recognition of viral RNA, the N-terminal caspase activat...

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Bibliographic Details
Main Authors: Takahisa Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-12224-7

Internet

https://doi.org/10.1038/s41598-017-12224-7

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