Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate antiviral signaling cascades, but the underlying structural mechanism is unknown. Here we report cryo-electron microscopi...

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Bibliographic Details
Main Authors: Hui Xu, Xiaojing He, Hui Zheng, Lily J Huang, Fajian Hou, Zhiheng Yu, Michael Jason de la Cruz, Brian Borkowski, Xuewu Zhang, Zhijian J Chen, Qiu-Xing Jiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
MAVS
innate immunity
prion-like filament
cryoEM reconstruction
three-stranded filament
Online Access:https://elifesciences.org/articles/01489

Internet

https://elifesciences.org/articles/01489

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