Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to caspase-8, blocks downstream signaling and thus c...

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Bibliographic Details
Main Authors: Linda Ebermann, Zsolt Ruzsics, Carlos A Guzmán, Nico van Rooijen, Rosaely Casalegno-Garduño, Ulrich Koszinowski, Luka Čičin-Šain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3521658?pdf=render

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http://europepmc.org/articles/PMC3521658?pdf=render

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