Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts

Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts

Oxidative stress plays a key role in systemic sclerosis (SSc) pathogenesis, and an altered redox homeostasis might be responsible for abnormal inflammatory status, fibrosis and tissue damage extension. In this study, we explored the effect of the phosphodiesterase type 5 inhibitor sildenafil in modu...

Full description

Bibliographic Details
Main Authors: Cristina Antinozzi, Paolo Sgrò, Francesco Marampon, Daniela Caporossi, Francesco Del Galdo, Ivan Dimauro, Luigi Di Luigi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biology
Subjects:
chemokines
systemic sclerosis
reactive oxygen species
fibrosis
sildenafil
Online Access:https://www.mdpi.com/2079-7737/10/6/491

Internet

https://www.mdpi.com/2079-7737/10/6/491

Similar Items