APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

Pancreatic cancer is a largely incurable disease, and increasing evidence supports strategies targeting multiple molecular mediators of critical functions of pancreatic ductal adenocarcinoma cells. Intracellular redox state modulates the activity of various signal transduction pathways and biologica...

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Bibliographic Details
Main Authors: Angelo A Cardoso, Yanlin Jiang, Meihua Luo, April M Reed, Safi Shahda, Ying He, Anirban Maitra, Mark R Kelley, Melissa L Fishel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3477158?pdf=render

Internet

http://europepmc.org/articles/PMC3477158?pdf=render

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