Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage

by Mark R Kelley, Jill C Fehrenbacher
Published 2017-01-01

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.

by Mark R Kelley, Yanlin Jiang, Chunlu Guo, April Reed, Hongdi Meng, Michael R Vasko
Published 2014-01-01

Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines

by Laura Cesaratto, Erika Codarin, Carlo Vascotto, Antonio Leonardi, Mark R. Kelley, Claudio Tiribelli, Gianluca Tell
Published 2013-01-01

APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

by Fenil Shah, Emery Goossens, Nadia M. Atallah, Michelle Grimard, Mark R. Kelley, Melissa L. Fishel
Published 2017-12-01

Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines.

by Laura Cesaratto, Erika Codarin, Carlo Vascotto, Antonio Leonardi, Mark R Kelley, Claudio Tiribelli, Gianluca Tell
Published 2013-01-01

Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines.

by Laura Cesaratto, Erika Codarin, Carlo Vascotto, Antonio Leonardi, Mark R. Kelley, Claudio Tiribelli, Gianluca Tell
Published 2013-01-01

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

by Fenil Shah, Derek Logsdon, Richard A. Messmann, Jill C. Fehrenbacher, Melissa L. Fishel, Mark R. Kelley
Published 2017-06-01

APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

by Angelo A Cardoso, Yanlin Jiang, Meihua Luo, April M Reed, Safi Shahda, Ying He, Anirban Maitra, Mark R Kelley, Melissa L Fishel
Published 2012-01-01

The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

by Rossana Domenis, Natascha Bergamin, Giuseppe Gianfranceschi, Carlo Vascotto, Milena Romanello, Silvia Rigo, Giovanna Vagnarelli, Massimo Faggiani, Piercamillo Parodi, Mark R Kelley, Carlo Alberto Beltrami, Daniela Cesselli, Gianluca Tell, Antonio Paolo Beltrami
Published 2014-01-01

Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target

by Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Published 2021-08-01