Evidence for an early innate immune response in the motor cortex of ALS

Evidence for an early innate immune response in the motor cortex of ALS

Abstract Background Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC chemokine receptor 2) signaling system has been strongly associated wit...

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Bibliographic Details
Main Authors: Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller, P. Hande Özdinler
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Upper motor neurons
Microglia
MCP1
CCR2
Online Access:http://link.springer.com/article/10.1186/s12974-017-0896-4

Internet

http://link.springer.com/article/10.1186/s12974-017-0896-4

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