Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.3.1.5) polymorphism on the N-acetylation of isoniazid (INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liq...

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Bibliographic Details
Main Authors: Mark A. Doll, Raúl A. Salazar-González, Srineil Bodduluri, David W. Hein
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Isoniazid
N-Acetyltransferase 2
Acetylation polymorphism
Human hepatocytes
Genotype
Phenotype
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517301600

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http://www.sciencedirect.com/science/article/pii/S2211383517301600

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