Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

BACKGROUND:Apoptosis is a hallmark of beta-cell death in both type 1 and type 2 diabetes mellitus. Understanding how apoptosis contributes to beta-cell turnover may lead to strategies to prevent progression of diabetes. A key mediator of apoptosis, mitochondrial function, and cell survival is apopto...

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Bibliographic Details
Main Authors: Fabienne T Schulthess, Sophie Katz, Amin Ardestani, Hiroshi Kawahira, Senta Georgia, Domenico Bosco, Anil Bhushan, Kathrin Maedler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2632884?pdf=render

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http://europepmc.org/articles/PMC2632884?pdf=render

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