Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

by Amin Ardestani, Amin Ardestani, Kathrin Maedler
Published 2020-10-01

Targeting glucose metabolism for treatment of COVID-19

by Amin Ardestani, Zahra Azizi
Published 2021-03-01

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

by Kanaka Durga Devi Gorrepati, Blaz Lupse, Karthika Annamalai, Ting Yuan, Kathrin Maedler, Amin Ardestani
Published 2018-03-01

An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis

by Kanaka Durga Devi Gorrepati, Wei He, Blaz Lupse, Ting Yuan, Kathrin Maedler, Amin Ardestani
Published 2018-03-01

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.

by Payal Shah, Navina Lueschen, Amin Ardestani, Jose Oberholzer, Johan Olerud, Per-Ola Carlsson, Kathrin Maedler
Published 2016-01-01

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

by Fabienne T Schulthess, Sophie Katz, Amin Ardestani, Hiroshi Kawahira, Senta Georgia, Domenico Bosco, Anil Bhushan, Kathrin Maedler
Published 2009-01-01

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

by Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Published 2021-08-01

Neratinib protects pancreatic beta cells in diabetes

by Amin Ardestani, Sijia Li, Karthika Annamalai, Blaz Lupse, Shirin Geravandi, Aleksandra Dobrowolski, Shan Yu, Siying Zhu, Tyler D. Baguley, Murali Surakattula, Janina Oetjen, Lena Hauberg-Lotte, Raquel Herranz, Sushil Awal, Delsi Altenhofen, Van Nguyen-Tran, Sean Joseph, Peter G. Schultz, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen, Kathrin Maedler
Published 2019-11-01