Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth

Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth

Activating transcription factor-5 (ATF5) is an anti-apoptotic factor and has been implicated in enhancing the survival of cancer cells under stress and in regulating the autophagy process. Targeting ATF5 in anticancer therapy may be particularly attractive because of its differential role in cancer...

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Bibliographic Details
Main Authors: Sarit Ben-Shmuel, Rola Rashed, Ran Rostoker, Elina Isakov, Zila Shen-Orr, Derek LeRoith
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Endocrinology
Subjects:
breast cancer
activating transcription factor-5
CD24
autophagy
insulin
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00173/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00173/full

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