Genome-wide search for Zelda-like chromatin signatures identifies GAF as a pioneer factor in early fly development

Genome-wide search for Zelda-like chromatin signatures identifies GAF as a pioneer factor in early fly development

Abstract Background The protein Zelda was shown to play a key role in early Drosophila development, binding thousands of promoters and enhancers prior to maternal-to-zygotic transition (MZT), and marking them for transcriptional activation. Recently, we showed that Zelda acts through specific chroma...

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Bibliographic Details
Main Authors: Arbel Moshe, Tommy Kaplan
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Epigenetics & Chromatin
Subjects:
Zelda
Maternal-to-zygotic transition
Histone modifications
Enhancers
Chromatin
Spectral clustering
Online Access:http://link.springer.com/article/10.1186/s13072-017-0141-5

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http://link.springer.com/article/10.1186/s13072-017-0141-5

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