Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

Abstract Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-specific methylation and nucleosomal profiling. Method...

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Bibliographic Details
Main Authors: Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Medical Genomics
Subjects:
Cell-free DNA
Origin
Absolute
APAP
Online Access:http://link.springer.com/article/10.1186/s12920-020-0705-2

Internet

http://link.springer.com/article/10.1186/s12920-020-0705-2

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