p53 Activity Results in DNA Replication Fork Processivity

p53 Activity Results in DNA Replication Fork Processivity

p53 induces cell death upon DNA damage, but this may not confer all of its tumor suppressor activity. We report that p53 activation enhances the processivity of DNA replication, as monitored by multi-label fiber assays, whereas removal of p53 reduces fork progression. This is observed in tumor-deriv...

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Bibliographic Details
Main Authors: Ina Klusmann, Sabrina Rodewald, Leonie Müller, Mascha Friedrich, Magdalena Wienken, Yizhu Li, Ramona Schulz-Heddergott, Matthias Dobbelstein
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314413

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http://www.sciencedirect.com/science/article/pii/S2211124716314413

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