Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target

by Ramona Schulz-Heddergott, Ute M. Moll
Published 2018-06-01

p53 Activity Results in DNA Replication Fork Processivity

by Ina Klusmann, Sabrina Rodewald, Leonie Müller, Mascha Friedrich, Magdalena Wienken, Yizhu Li, Ramona Schulz-Heddergott, Matthias Dobbelstein
Published 2016-11-01

The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells

by Luisa Klemke, Clara F. Fehlau, Nadine Winkler, Felicia Toboll, Shiv K. Singh, Ute M. Moll, Ramona Schulz-Heddergott
Published 2021-06-01

Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer

by Luisa Klemke, Tiago De Oliveira, Daria Witt, Nadine Winkler, Hanibal Bohnenberger, Richard Bucala, Lena-Christin Conradi, Ramona Schulz-Heddergott
Published 2021-02-01

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

by Tamara Isermann, Özge Çiçek Şener, Adrian Stender, Luisa Klemke, Nadine Winkler, Albrecht Neesse, Jinyu Li, Florian Wegwitz, Ute M. Moll, Ramona Schulz-Heddergott
Published 2021-06-01