Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models.
Bibliographic Details
| Main Authors: |
Yuichiro Mita,
Kaho Nakayama,
Shogo Inari,
Yukina Nishito,
Yuya Yoshioka,
Naoko Sakai,
Kanade Sotani,
Takahiro Nagamura,
Yuki Kuzuhara,
Kumi Inagaki,
Miki Iwasaki,
Hirofumi Misu,
Masaya Ikegawa,
Toshinari Takamura,
Noriko Noguchi,
Yoshiro Saito |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01863-z
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