Thrombin regulation of synaptic transmission and plasticity: implications for health and disease.

Thrombin regulation of synaptic transmission and plasticity: implications for health and disease.

Thrombin, a serine protease involved in the blood coagulation cascade has been shown to affect neural function following blood-brain barrier breakdown. However, several lines of evidence exist that thrombin is also expressed in the brain under physiological conditions, suggesting an involvement of t...

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Bibliographic Details
Main Authors: Marina eBen Shimon, Maximilian eLenz, Benno eIkenberg, Denise eBecker, Efrat eShavit Stein, Joab eChapman, David eTanne, Chaim G Pick, Ilan eBlatt, Miri eNeufeld, Andreas eVlachos, Nicola eMaggio
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
Thrombin
long term potentiation
synaptic plasticity
Clotting factors
Proteases activated receptor 1 (PAR1)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00151/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00151/full

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