Specific Behavioral Responses Rather than Autonomic Responses Can Indicate and Quantify Acute Pain Among Individuals with Intellectual and Developmental Disabilities

by Ruth Defrin, Tali Benromano, Chaim G. Pick
Published 2021-02-01

The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice

by Vardit Rubovitch, Shahaf Edut, Rive Sarfstein, Haim Werner, Chaim G. Pick
Published 2010-05-01

Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury

by Miaad Bader, Yazhou Li, David Tweedie, Nathan A. Shlobin, Adi Bernstein, Vardit Rubovitch, Luis B. Tovar-y-Romo, Luis B. Tovar-y-Romo, Richard D. DiMarchi, Barry J. Hoffer, Nigel H. Greig, Chaim G. Pick, Chaim G. Pick, Chaim G. Pick
Published 2020-01-01

Role of Thrombin in Central Nervous System Injury and Disease

by Nathan A. Shlobin, Meirav Har-Even, Ze’ev Itsekson-Hayosh, Sagi Harnof, Chaim G. Pick
Published 2021-04-01

PKC activator therapeutic for mild traumatic brain injury in mice

by Ofer Zohar, Rotem Lavy, Xiaomei Zi, Thomas J. Nelson, Jarin Hongpaisan, Chaim G. Pick, D.L. Alkon
Published 2011-02-01

Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine

by Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang, Nigel H. Greig
Published 2017-09-01

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI).

by Renana Baratz-Goldstein, Hanna Deselms, Leore Raphael Heim, Lena Khomski, Barry J Hoffer, Daphne Atlas, Chaim G Pick
Published 2016-01-01

Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α.

by Lital Rachmany, David Tweedie, Vardit Rubovitch, Qian-Sheng Yu, Yazhou Li, Jia-Yi Wang, Chaim G Pick, Nigel H Greig
Published 2013-01-01

Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury

by Marina Ben Shimon, Efrat Shavit-Stein, Efrat Shavit-Stein, Keren Altman, Chaim G. Pick, Nicola Maggio, Nicola Maggio, Nicola Maggio
Published 2020-01-01

Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury

by David Tweedie, Hanuma Kumar Karnati, Roger Mullins, Chaim G Pick, Barry J Hoffer, Edward J Goetzl, Dimitrios Kapogiannis, Nigel H Greig
Published 2020-08-01

Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome

by David Tanne, Aviva Katzav, Orit Beilin, Nikolaos C. Grigoriadis, Miri Blank, Chaim G. Pick, Philipp von Landenberg, Yehuda Shoenfeld, Joab Chapman
Published 2008-04-01

Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus.

by Marina Ben Shimon, Talya Zeimer, Efrat Shavit Stein, Avital Artan-Furman, Sagi Harnof, Joab Chapman, Arik Eisenkraft, Chaim G Pick, Nicola Maggio
Published 2017-01-01

Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury

by David Tweedie, Lital Rachmany, Vardit Rubovitch, Yongqing Zhang, Kevin G. Becker, Evelyn Perez, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig
Published 2013-06-01

Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives

by Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith R. Homberg, Martien J. H. Kas, Helmut W. Kessels, Bastijn Koopmans, Michael J. Krashes, Vaishnav Krishnan, Sreemathi Logan, Maarten Loos, Katharine E. McCann, Qendresa Parduzi, Chaim G. Pick, Chaim G. Pick, Chaim G. Pick, Thomas D. Prevot, Gernot Riedel, Lianne Robinson, Mina Sadighi, August B. Smit, William Sonntag, Reinko F. Roelofs, Ruud A.J. Tegelenbosch, Lucas P.J.J. Noldus, Lucas P.J.J. Noldus
Published 2021-09-01

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice

by Daniela Lecca, Miaad Bader, David Tweedie, Alexander F. Hoffman, Yoo Jin Jung, Shin-Chang Hsueh, Barry J. Hoffer, Robert E. Becker, Chaim G. Pick, Carl R. Lupica, Nigel H. Greig
Published 2019-10-01

Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration

by Lital Rachmany, David Tweedie, Vardit Rubovitch, Yazhou Li, Harold W. Holloway, Dong Seok Kim, Whitney A. Ratliff, Jessica N. Saykally, Bruce A. Citron, Barry J. Hoffer, Nigel H. Greig, Chaim G. Pick
Published 2017-06-01

Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury

by Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Published 2019-04-01

Thrombin regulation of synaptic transmission and plasticity: implications for health and disease.

by Marina eBen Shimon, Maximilian eLenz, Benno eIkenberg, Denise eBecker, Efrat eShavit Stein, Joab eChapman, David eTanne, Chaim G Pick, Ilan eBlatt, Miri eNeufeld, Andreas eVlachos, Nicola eMaggio
Published 2015-04-01

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanism...

by David Tweedie, Koji Fukui, Yazhou Li, Qian-Sheng Yu, Shani Barak, Ian A Tamargo, Vardit Rubovitch, Harold W Holloway, Elin Lehrmann, William H Wood, Yongqing Zhang, Kevin G Becker, Evelyn Perez, Henriette Van Praag, Yu Luo, Barry J Hoffer, Robert E Becker, Chaim G Pick, Nigel H Greig
Published 2016-01-01