Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters.

Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters.

The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like motifs (ZREs), induces expression of the BRLF1 (R) and BRRF1 (Na) viral proteins, which cooperatively activate trans...

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Bibliographic Details
Main Authors: Sarah J Dickerson, Yongna Xing, Amanda R Robinson, William T Seaman, Henri Gruffat, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2654727?pdf=render

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http://europepmc.org/articles/PMC2654727?pdf=render

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