DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.

DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.

A prerequisite of hypertrophic response of the myocardium is an increase in protein synthesis. A central regulator of translation initiation is Eukaryotic initiation factor 2B (eIF2B). Here we assessed the hypothesis that regulation of protein synthesis via eIF2Bε is essential to cardiac hypertrophi...

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Bibliographic Details
Main Authors: Celine S Weiss, Marco M Ochs, Marco Hagenmueller, Marcus R Streit, Pratima Malekar, Johannes H Riffel, Sebastian J Buss, Karl H Weiss, Junichi Sadoshima, Hugo A Katus, Stefan E Hardt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3762802?pdf=render

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http://europepmc.org/articles/PMC3762802?pdf=render

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