Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases

by Junichi Sadoshima, Richard N. Kitsis, Sebastiano Sciarretta, Sebastiano Sciarretta
Published 2021-01-01

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.

by Takanobu Yamamoto, Jaemin Byun, Peiyong Zhai, Yoshiyuki Ikeda, Shinichi Oka, Junichi Sadoshima
Published 2014-01-01

New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart

by Yoshiyuki Ikeda, Sebastiano Sciarretta, Narayani Nagarajan, Speranza Rubattu, Massimo Volpe, Giacomo Frati, Junichi Sadoshima
Published 2014-01-01

The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling.

by Smail Messaoudi, An Di Zhang, Violaine Griol-Charhbili, Brigitte Escoubet, Junichi Sadoshima, Nicolette Farman, Frederic Jaisser
Published 2012-01-01

Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.

by Nirmala Hariharan, Yoshiyuki Ikeda, Chull Hong, Ralph R Alcendor, Soichiro Usui, Shumin Gao, Yasuhiro Maejima, Junichi Sadoshima
Published 2013-01-01

An Ideal PPAR Response Element Bound to and Activated by PPARα.

by John Tzeng, Jaemin Byun, Ji Yeon Park, Takanobu Yamamoto, Kevin Schesing, Bin Tian, Junichi Sadoshima, Shin-Ichi Oka
Published 2015-01-01

β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes

by Shin-ichi Oka, Fan Tang, Adave Chin, Guersom Ralda, Xiaoyong Xu, Chengchen Hu, Zhi Yang, Maha Abdellatif, Junichi Sadoshima
Published 2021-07-01

Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules.

by Ji Yeon Park, Wencheng Li, Dinghai Zheng, Peiyong Zhai, Yun Zhao, Takahisa Matsuda, Stephen F Vatner, Junichi Sadoshima, Bin Tian
Published 2011-01-01

Autocrine Bradykinin Release Promotes Ischemic Preconditioning-Induced Cytoprotection in Bovine Aortic Endothelial Cells

by Alessandro Bellis, Daniela Sorriento, Antonella Fiordelisi, Raffaele Izzo, Junichi Sadoshima, Ciro Mauro, Federica Cerasuolo, Costantino Mancusi, Emanuele Barbato, Emanuele Pilato, Bruno Trimarco, Carmine Morisco
Published 2020-04-01

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

by Matthew J Brody, Timothy A Hacker, Jitandrakumar R Patel, Li Feng, Junichi Sadoshima, Sergei G Tevosian, Ravi C Balijepalli, Richard L Moss, Youngsook Lee
Published 2012-01-01

NOX4 Mediates <i>Pseudomonas Aeruginosa</i>-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium

by Panfeng Fu, Ramaswamy Ramchandran, Tara Sudhadevi, Prasanth P.K. Kumar, Yashaswin Krishnan, Yuru Liu, Yutong Zhao, Narasimham L. Parinandi, Anantha Harijith, Junichi Sadoshima, Viswanathan Natarajan
Published 2021-03-01

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

by Sebastiano Sciarretta, Peiyong Zhai, Yasuhiro Maejima, Dominic P. Del Re, Narayani Nagarajan, Derek Yee, Tong Liu, Mark A. Magnuson, Massimo Volpe, Giacomo Frati, Hong Li, Junichi Sadoshima
Published 2015-04-01

DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.

by Celine S Weiss, Marco M Ochs, Marco Hagenmueller, Marcus R Streit, Pratima Malekar, Johannes H Riffel, Sebastian J Buss, Karl H Weiss, Junichi Sadoshima, Hugo A Katus, Stefan E Hardt
Published 2013-01-01

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids

by Allan Sauvat, Guo Chen, Kevin Müller, Mingming Tong, Fanny Aprahamian, Sylvère Durand, Giulia Cerrato, Lucillia Bezu, Marion Leduc, Joakim Franz, Patrick Rockenfeller, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer
Published 2018-04-01

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins

by Hyeog Kang, Shinichi Oka, Duck-Yeon Lee, Junhong Park, Angel M. Aponte, Young-Sang Jung, Jacob Bitterman, Peiyong Zhai, Yi He, Hamed Kooshapur, Rodolfo Ghirlando, Nico Tjandra, Sean B. Lee, Myung K. Kim, Junichi Sadoshima, Jay H. Chung
Published 2017-05-01

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

by Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutierrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadic, Martina Bergmann, Sebastian J Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer
Published 2019-11-01

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

by Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn II, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson
Published 2017-01-01

Aspirin Recapitulates Features of Caloric Restriction

by Federico Pietrocola, Francesca Castoldi, Maria Markaki, Sylvie Lachkar, Guo Chen, David P. Enot, Sylvere Durand, Noelie Bossut, Mingming Tong, Shoaib A. Malik, Friedemann Loos, Nicolas Dupont, Guillermo Mariño, Nejma Abdelkader, Frank Madeo, Maria Chiara Maiuri, Romano Kroemer, Patrice Codogno, Junichi Sadoshima, Nektarios Tavernarakis, Guido Kroemer
Published 2018-02-01

Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.

by Shin-Ichi Oka, Amira D Sabry, Amanda K Horiuchi, Keiko M Cawley, Sean A O'Very, Maria A Zaitsev, Thirupura S Shankar, Jaemin Byun, Risa Mukai, Xiaoyong Xu, Natalia S Torres, Anil Kumar, Masayuki Yazawa, Jing Ling, Iosif Taleb, Yukio Saijoh, Stavros G Drakos, Junichi Sadoshima, Junco S Warren
Published 2020-01-01

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

by Shohei Ikeda, MD, PhD, Risa Mukai, MD, PhD, Wataru Mizushima, MD, PhD, Peiyong Zhai, MD, PhD, Shin-ichi Oka, PhD, Michinari Nakamura, MD, PhD, Dominic P. Del Re, PhD, Sebastiano Sciarretta, MD, PhD, Chiao-Po Hsu, MD, PhD, Hiroaki Shimokawa, MD, PhD, Junichi Sadoshima, MD, PhD
Published 2019-09-01