Identification of a Compound That Inhibits the Growth of Gram-Negative Bacteria by Blocking BamA–BamD Interaction

Identification of a Compound That Inhibits the Growth of Gram-Negative Bacteria by Blocking BamA–BamD Interaction

The demand for novel antibiotics is imperative for drug-resistant Gram-negative bacteria which causes diverse intractable infection disease in clinic. Here, a comprehensive screening was implemented to identify potential agents that disrupt the assembly of β-barrel outer-membrane proteins (OMPs) in...

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Bibliographic Details
Main Authors: Yan Li, Xiaohong Zhu, Jing Zhang, Yuan Lin, Xuefu You, Minghua Chen, Yanchang Wang, Ningyu Zhu, Shuyi Si
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
outer-membrane proteins
Escherichia coli
BamA–BamD
yeast two-hybrid
antibacterial agent
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01252/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01252/full

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