Design, automated synthesis and immunological evaluation of NOD2-ligand–antigen conjugates

Design, automated synthesis and immunological evaluation of NOD2-ligand–antigen conjugates

The covalent attachment of an innate immune system stimulating agent to an antigen can provide active vaccine modalities capable of eliciting a potent immune response against the incorporated antigen. Here we describe the design, automated synthesis and immunological evaluation of a set of four mura...

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Bibliographic Details
Main Authors: Marian M. J. H. P. Willems, Gijs G. Zom, Nico Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov
Format: Article
Language:English
Published: Beilstein-Institut 2014-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
automated synthesis
glycopeptide
innate immunity
muramyl dipeptide
NOD2 receptor
solid phase synthesis
Online Access:https://doi.org/10.3762/bjoc.10.148

Internet

https://doi.org/10.3762/bjoc.10.148

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