Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.

Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.

Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi microparticles, in contrast to free MPL, resulted in the induction of local inflammat...

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Bibliographic Details
Main Authors: Ismail M Meraz, Claire H Hearnden, Xuewu Liu, Marie Yang, Laura Williams, David J Savage, Jianhua Gu, Jessica R Rhudy, Kenji Yokoi, Ed C Lavelle, Rita E Serda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988134?pdf=render

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http://europepmc.org/articles/PMC3988134?pdf=render

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