Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

by Craig P. McEntee, Craig P. McEntee, Conor M. Finlay, Conor M. Finlay, Ed C. Lavelle, Ed C. Lavelle
Published 2019-06-01

Editorial: Challenges in Vaccinology

by Ed C. Lavelle, Rita Carsetti, Winfried F. Pickl, Ursula Wiedermann
Published 2020-12-01

Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells.

by Graham A Tynan, Anne McNaughton, Andrew Jarnicki, Takao Tsuji, Ed C Lavelle
Published 2012-01-01

The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation

by Filipa Lebre, Rukmani Sridharan, Michael J. Sawkins, Daniel J. Kelly, Fergal J. O’Brien, Ed C. Lavelle
Published 2017-06-01

UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.

by Emma B O'Connor, Natalia Muñoz-Wolf, Gemma Leon, Ed C Lavelle, Kingston H G Mills, Patrick T Walsh, Richard K Porter
Published 2020-01-01

Alum Activates the Bovine NLRP3 Inflammasome

by Ciaran Harte, Ciaran Harte, Aoife L. Gorman, S. McCluskey, Michael Carty, Andrew G. Bowie, C. J. Scott, Kieran G. Meade, Ed C. Lavelle
Published 2017-11-01

Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines

by Aqel Albutti, Stephanie Longet, Craig P. McEntee, Shauna Quinn, Alex Liddicoat, Cristiana Rîmniceanu, Nils Lycke, Lydia Lynch, Susanna Cardell, Ed C. Lavelle
Published 2021-06-01

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

by Louis M. Scott, Emma E. Vincent, Natalie Hudson, Chris Neal, Nicholas Jones, Ed C. Lavelle, Matthew Campbell, Andrew P. Halestrap, Andrew D. Dick, Sofia Theodoropoulou
Published 2021-04-01

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

by Danielle M. Clancy, Graeme P. Sullivan, Hannah B.T. Moran, Conor M. Henry, Emer P. Reeves, Noel G. McElvaney, Ed C. Lavelle, Seamus J. Martin
Published 2018-03-01

Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.

by Pádraig J Ross, Caroline E Sutton, Sarah Higgins, Aideen C Allen, Kevin Walsh, Alicja Misiak, Ed C Lavelle, Rachel M McLoughlin, Kingston H G Mills
Published 2013-01-01

Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.

by Ismail M Meraz, Claire H Hearnden, Xuewu Liu, Marie Yang, Laura Williams, David J Savage, Jianhua Gu, Jessica R Rhudy, Kenji Yokoi, Ed C Lavelle, Rita E Serda
Published 2014-01-01

Technological Approaches for Improving Vaccination Compliance and Coverage

by Céline Lemoine, Aneesh Thakur, Danina Krajišnik, Romain Guyon, Stephanie Longet, Agnieszka Razim, Sabina Górska, Ivana Pantelić, Tanja Ilić, Ines Nikolić, Ed C. Lavelle, Andrzej Gamian, Snežana Savić, Anita Milicic
Published 2020-06-01

A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma.

by Sergio Arancibia, Cecilia Espinoza, Fabián Salazar, Miguel Del Campo, Ricardo Tampe, Ta-Ying Zhong, Pablo De Ioannes, Bruno Moltedo, Jorge Ferreira, Ed C Lavelle, Augusto Manubens, Alfredo E De Ioannes, María Inés Becker
Published 2014-01-01

TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals

by José M. Jiménez, Michelle L. Salazar, Sergio Arancibia, Javiera Villar, Fabián Salazar, Fabián Salazar, Gordon D. Brown, Ed C. Lavelle, Luisa Martínez-Pomares, Jafet Ortiz-Quintero, Sergio Lavandero, Augusto Manubens, María Inés Becker, María Inés Becker
Published 2019-05-01

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

by Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
Published 2010-11-01

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

by Emer E. Hackett, Hugo Charles-Messance, Seónadh M. O’Leary, Laura E. Gleeson, Natalia Muñoz-Wolf, Sarah Case, Anna Wedderburn, Daniel G.W. Johnston, Michelle A. Williams, Alicia Smyth, Mireille Ouimet, Kathryn J. Moore, Ed C. Lavelle, Sinéad C. Corr, Stephen V. Gordon, Joseph Keane, Frederick J. Sheedy
Published 2020-01-01

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

by Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin
Published 2015-01-01

Caspase-11 promotes allergic airway inflammation

by Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Published 2020-02-01

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

by Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Published 2021-03-01