RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane

RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane

Abstract The receptor for advanced glycation end-products (RAGE) and the G protein-coupled angiotensin II (AngII) type I receptor (AT1) play a central role in cardiovascular diseases. It was recently reported that RAGE modifies AngII-mediated AT1 activation via the membrane oligomeric complex of the...

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Bibliographic Details
Main Authors: Serina Yokoyama, Tatsuo Kawai, Koichi Yamamoto, Huang Yibin, Hiroko Yamamoto, Akemi Kakino, Hikari Takeshita, Yoichi Nozato, Taku Fujimoto, Kazuhiro Hongyo, Toshimasa Takahashi, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Tatsuya Sawamura, Hiromi Rakugi
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85312-4

Internet

https://doi.org/10.1038/s41598-021-85312-4

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