Mechanisms of buffer therapy resistance

Many studies have shown that the acidity of solid tumors contributes to local invasion and metastasis. Oral pH buffers can specifically neutralize the acidic pH of tumors and reduce the incidence of local invasion and metastatic formation in multiple murine models. However, this effect is not unive...

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Bibliographic Details
Main Authors: Kate M. Bailey, Jonathan W. Wojtkowiak, Heather H. Cornnell, Maria C. Ribeiro, Yoganand Balagurunathan, Arig Ibrahim Hashim, Robert J. Gillies
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861400044X