Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïv...

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Main Authors: Mohammad Alkhatib, Velia Chiara Di Maio, Valentina De Murtas, Ennio Polilli, Martina Milana, Elisabetta Teti, Gianluca Fiorentino, Vincenza Calvaruso, Silvia Barbaliscia, Ada Bertoli, Rossana Scutari, Luca Carioti, Valeria Cento, Maria Mercedes Santoro, Alessandro Orro, Ivana Maida, Ilaria Lenci, Loredana Sarmati, Antonio Craxì, Caterina Pasquazzi, Giustino Parruti, Sergio Babudieri, Luciano Milanesi, Massimo Andreoni, Mario Angelico, Carlo Federico Perno, Francesca Ceccherini-Silberstein, Valentina Svicher, Romina Salpini, on behalf of HIRMA (Hepatocarcinoma Innovative Research MArkers) and Fondazione Vironet C (HCV Virology Italian Resistance
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
hepatitis C virus
hepatocellular carcinoma
cirrhosis
NS5A
genotype 1b
genetic variability
Online Access:https://www.mdpi.com/1999-4915/13/5/743

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https://www.mdpi.com/1999-4915/13/5/743

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