Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

Protamine sulfate (PS) is the only available option to reverse the anticoagulant activity of unfractionated heparin (UFH), however it can cause cardiovascular and respiratory complications. We explored the toxicity of PS and its complexes with UFH in zebrafish, rats, and mice. The involvement of nit...

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Bibliographic Details
Main Authors: Joanna Miklosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
cardiac toxicity
heparin
hERG
ion channels
protamine
respiratory toxicity
Online Access:https://www.mdpi.com/1999-4923/13/3/359

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https://www.mdpi.com/1999-4923/13/3/359

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