Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including the substantia nigra pars compacta (SNpc), where marked loss of dopaminergic neurons is also observed. Yet, the relationship betwee...

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Bibliographic Details
Main Authors: Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
Ubiquitin-proteasome system
α-Synuclein
Neurodegeneration
Online Access:https://doi.org/10.1186/s40478-020-0894-0

Internet

https://doi.org/10.1186/s40478-020-0894-0

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