Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Ex...

by James B Koprich, Tom H Johnston, Gabriela Reyes, Vanessa Omana, Jonathan M Brotchie
Published 2016-01-01

Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.

by James B Koprich, Tom H Johnston, Philippe Huot, M Gabriela Reyes, Maria Espinosa, Jonathan M Brotchie
Published 2011-01-01

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

by Simoneide S. Titze-de-Almeida, Cristina Soto-Sánchez, Eduardo Fernandez, James B. Koprich, Jonathan M. Brotchie, Ricardo Titze-de-Almeida
Published 2020-03-01

Non-steric-zipper models for pathogenic α-synuclein conformers

by Brock Schuman, Amy Won, Koroboshka Brand-Arzamendi, James B. Koprich, Xiao-Yan Wen, Patrick A. Howson, Jonathan M. Brotchie, Christopher M. Yip
Published 2018-06-01

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

by Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Published 2020-02-01

Corrigendum to “Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism” [Neurobiol....

by Jacqueline A. Gleave, Lindsay R. Arathoon, Dennison Trinh, Kristin E. Lizal, Nicolas Giguère, James E.M. Barber, Zainab Najarali, M. Hassan Khan, Sherri L. Thiele, Mahin S. Semmen, James B. Koprich, Jonathan M. Brotchie, James H. Eubanks, Louis-Eric Trudeau, Joanne E. Nash
Published 2018-08-01

Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism

by Jacqueline A. Gleave, Lindsay R. Arathoon, Dennison Trinh, Kristin E. Lizal, Nicolas Giguère, James H.M. Barber, Zainab Najarali, M. Hassan Khan, Sherri L. Thiele, Mahin S. Semmen, James B. Koprich, Jonathan M. Brotchie, James H. Eubanks, Louis-Eric Trudeau, Joanne E. Nash
Published 2017-10-01