Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K<sub>2(20)</sub>, Could Overcome the Photoinstability and Phototoxicity of Vitamin K<sub>2(20)</sub>

Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K<sub>2(20)</sub>, Could Overcome the Photoinstability and Phototoxicity of Vitamin K<sub>2(20)</sub>

The effective delivery of menahydroquinone-4 (MKH), an active form of menaquinone-4 (MK-4, vitamin K<sub>2(20)</sub>), to the skin is beneficial in the treatment of various skin pathologies. However, its delivery through the application of MK-4 to the skin is hampered due to the photoins...

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Bibliographic Details
Main Authors: Shotaro Goto, Shuichi Setoguchi, Hirofumi Yamakawa, Daisuke Watase, Kazuki Terada, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
menaquinone-4
menahydroquinone-4
prodrug
drug delivery system
phototoxicity
photostability
photodegradation
skin application
vitamin K
Online Access:https://www.mdpi.com/1422-0067/20/10/2548

Internet

https://www.mdpi.com/1422-0067/20/10/2548

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