Effects of oral administration of collagen peptides on skin collagen content and its underlying mechanism using a newly developed low collagen skin mice model

by Akinori Haratake, Daisuke Watase, Takuya Fujita, Shuichi Setoguchi, Kazuhisa Matsunaga, Jiro Takata
Published 2015-06-01

The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells

by Kazuki Terada, Yukari Matsushima, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Atsushi Ishige, Koji Chiba
Published 2018-08-01

Menahydroquinone-4 Prodrug: A Promising Candidate Anti-Hepatocellular Carcinoma Agent

by Munechika Enjoji, Daisuke Watase, Kazuhisa Matsunaga, Mariko Kusuda, Nami Nagata-Akaho, Yoshiharu Karube, Jiro Takata
Published 2015-07-01

Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K₂₍₂₀₎, Could Overcome the Photoinstability and Phototoxicity of Vitamin K₂₍₂₀₎

by Shotaro Goto, Shuichi Setoguchi, Hirofumi Yamakawa, Daisuke Watase, Kazuki Terada, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Published 2019-05-01

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

by Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Published 2020-01-01

Novel d-γ-tocopherol derivative as a prodrug for d-γ-tocopherol and a two-step prodrug for S-γ-CEHC

by Jiro Takata, Ryoji Hidaka, Akihiko Yamasaki, Akihiro Hattori, Takeshi Fukushima, Maiko Tanabe, Kazuhisa Matsunaga, Yoshiharu Karube, Kazuhiro Imai
Published 2002-12-01

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.

by Kazuki Terada, Keisuke Migita, Yukari Matsushima, Yumi Sugimoto, Chiaki Kamei, Taichi Matsumoto, Masayoshi Mori, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube
Published 2018-01-01

Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells

by Shuichi Setoguchi, Daisuke Watase, Kazuhisa Matsunaga, Hirofumi Yamakawa, Shotaro Goto, Kazuki Terada, Kenji Ohe, Munechika Enjoji, Yoshiharu Karube, Jiro Takata
Published 2018-07-01

Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study

by Kazuki Terada, Ayumi Murata, Erina Toki, Shotaro Goto, Hirofumi Yamakawa, Shuichi Setoguchi, Daisuke Watase, Mitsuhisa Koga, Jiro Takata, Kazuhisa Matsunaga, Yoshiharu Karube
Published 2020-09-01

Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K₂₍₂₀₎, on All-Trans Retinoic Acid-Resistant HL60 Cell Line

by Hirofumi Yamakawa, Shuichi Setoguchi, Shotaro Goto, Daisuke Watase, Kazuki Terada, Nami Nagata-Akaho, Erina Toki, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Published 2021-05-01