A Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study

A Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study

We examined the neuro/axono-protective potential of a novel poly (ADP-ribose) polymerase (PARP) inhibitor L-2286 in a rat impact acceleration brain injury model. Male Wistar rats (n = 70) weighing 300-350 grams were used to determine the most effective intracerebroventricular (i.c.v.) dose of L-2286...

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Bibliographic Details
Main Authors: Erzsébet Kövesdi, Péter Bukovics, Valérie Besson, József Nyirádi, János Lückl, József Pál, Balázs Sümegi, Tamás Dóczi, István Hernádi, András Büki
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:International Journal of Molecular Sciences
Subjects:
PARP-inhibitor
impact acceleration model
traumatic brain injury
Online Access:http://www.mdpi.com/1422-0067/11/4/1253/

Internet

http://www.mdpi.com/1422-0067/11/4/1253/

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