Mitochondrial Protection by PARP Inhibition

by Ferenc Gallyas Jr, Balazs Sumegi
Published 2020-04-01

Role of Akt Activation in PARP Inhibitor Resistance in Cancer

by Ferenc Gallyas Jr, Balazs Sumegi, Csaba Szabo
Published 2020-02-01

Synthesis of paramagnetic and diamagnetic flavones and flavanones

by Tamás Kálai, Gyõzõ Kulcsár, Erzsébet Õsz, József Jekõ, Balázs Sümegi, Kálmán Hideg
Published 2004-05-01

Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model

by Adam Riba, Laszlo Deres, Balazs Sumegi, Kalman Toth, Eszter Szabados, Robert Halmosi
Published 2017-01-01

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

by Anna Maria Cseh, Anna Maria Cseh, Zsolt Fabian, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Aliz Szabo, Aliz Szabo, Krisztian Eros, Krisztian Eros, Krisztian Eros, Maria Eugenia Soriano, Maria Eugenia Soriano, Ferenc Gallyas, Ferenc Gallyas, Ferenc Gallyas, Luca Scorrano, Luca Scorrano, Balazs Sumegi, Balazs Sumegi, Balazs Sumegi
Published 2019-05-01

Synthesis and study of new 4-quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)

by Gyozo Kulcsar, Tamas Kalai, ErzsebetOsz, Cecilia P. Sar, Jozsef Jeko, Balazs Sumegi, Kalman Hideg
Published 2003-06-01

PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade.

by Karoly Kalmar-Nagy, Peter Degrell, Aliz Szabo, Katalin Sumegi, Istvan Wittmann, Ferenc Gallyas, Balazs Sumegi
Published 2013-01-01

BGP-15 Protects against Heart Failure by Enhanced Mitochondrial Biogenesis and Decreased Fibrotic Remodelling in Spontaneously Hypertensive Rats

by Orsolya Horvath, Katalin Ordog, Kitti Bruszt, Laszlo Deres, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Published 2021-01-01

Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases and Akt.

by Tamas Kiss, Krisztina Kovacs, Andras Komocsi, Adrienn Tornyos, Petra Zalan, Balazs Sumegi, Ferenc Gallyas, Krisztina Kovacs
Published 2014-01-01

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species.

by Katalin Sumegi, Katalin Fekete, Csenge Antus, Balazs Debreceni, Eniko Hocsak, Ferenc Gallyas, Balazs Sumegi, Aliz Szabo
Published 2017-01-01

Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol.

by Eszter Bognar, Zsolt Sarszegi, Aliz Szabo, Balazs Debreceni, Nikoletta Kalman, Zsuzsanna Tucsek, Balazs Sumegi, Ferenc Gallyas
Published 2013-01-01

Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure.

by Adam Riba, Laszlo Deres, Krisztian Eros, Aliz Szabo, Klara Magyar, Balazs Sumegi, Kalman Toth, Robert Halmosi, Eszter Szabados
Published 2017-01-01

A Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study

by Erzsébet Kövesdi, Péter Bukovics, Valérie Besson, József Nyirádi, János Lückl, József Pál, Balázs Sümegi, Tamás Dóczi, István Hernádi, András Büki
Published 2010-03-01

Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model.

by Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H J Ramadan, Balazs Sumegi, Ferenc Gallyas
Published 2020-01-01

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats.

by Krisztian Eros, Klara Magyar, Laszlo Deres, Arpad Skazel, Adam Riba, Zoltan Vamos, Tamas Kalai, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Published 2017-01-01

Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways.

by Zita Bognar, Katalin Fekete, Csenge Antus, Eniko Hocsak, Rita Bognar, Antal Tapodi, Arpad Boronkai, Nelli Farkas, Ferenc Gallyas, Balazs Sumegi, Arpad Szanto
Published 2017-01-01

Resveratrol Improves Heart Function by Moderating Inflammatory Processes in Patients with Systolic Heart Failure

by Roland Gal, Laszlo Deres, Orsolya Horvath, Krisztian Eros, Barbara Sandor, Peter Urban, Szilvia Soos, Zsolt Marton, Balazs Sumegi, Kalman Toth, Tamas Habon, Robert Halmosi
Published 2020-11-01

PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.

by Laszlo Deres, Eva Bartha, Anita Palfi, Krisztian Eros, Adam Riba, Janos Lantos, Tamas Kalai, Kalman Hideg, Balazs Sumegi, Ferenc Gallyas, Kalman Toth, Robert Halmosi
Published 2014-01-01

Cyclophilin D‐dependent mitochondrial permeability transition amplifies inflammatory reprogramming in endotoxemia

by Balazs Veres, Krisztian Eros, Csenge Antus, Nikoletta Kalman, Fruzsina Fonai, Peter Balazs Jakus, Eva Boros, Zoltan Hegedus, Istvan Nagy, Laszlo Tretter, Ferenc Gallyas Jr, Balazs Sumegi
Published 2021-03-01