Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.

<h4>Purpose</h4>We previously reported that inhibitory G protein (Gi) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes of AC in the heart are AC5 and AC6. The aim of this study w...

Full description

Bibliographic Details
Main Authors: Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218110

Internet

https://doi.org/10.1371/journal.pone.0218110

Similar Items