Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

by Caroline Bull Melsom, Øivind Ørstavik, Jan-Bjørn Osnes, Tor Skomedal, Finn Olav Levy, Kurt Allen Krobert
Published 2014-01-01

The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.

by Øivind Ørstavik, Ornella Manfra, Kjetil Wessel Andressen, Geir Øystein Andersen, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Kurt Allen Krobert
Published 2015-01-01

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

by Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Ornella eManfra, Ornella eManfra, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kurt Allen Krobert, Kurt Allen Krobert, Kurt Allen Krobert, Angela eMessina, Angela eMessina, Finn Olav eLevy, Finn Olav eLevy, Finn Olav eLevy, Salvatore eGuccione
Published 2015-05-01

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.

by Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert
Published 2019-01-01