Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

The mutational outcome of CRISPR-Cas9 editing can be both predictable and targeted. Here the authors show that ATM inhibitor KU-60019 increases 1 bp insertions at the targeted locus.

Bibliographic Details
Main Authors: Heysol C. Bermudez-Cabrera, Sannie Culbertson, Sammy Barkal, Benjamin Holmes, Max W. Shen, Sophia Zhang, David K. Gifford, Richard I. Sherwood
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25415-8

Internet

https://doi.org/10.1038/s41467-021-25415-8

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