Machine learning based CRISPR gRNA design for therapeutic exon skipping.

by Wilson Louie, Max W Shen, Zakir Tahiry, Sophia Zhang, Daniel Worstell, Christopher A Cassa, Richard I Sherwood, David K Gifford
Published 2021-01-01

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

by Heysol C. Bermudez-Cabrera, Sannie Culbertson, Sammy Barkal, Benjamin Holmes, Max W. Shen, Sophia Zhang, David K. Gifford, Richard I. Sherwood
Published 2021-08-01

Detection of gene cis-regulatory element perturbations in single-cell transcriptomes.

by Grace Hui Ting Yeo, Oscar Juez, Qing Chen, Budhaditya Banerjee, Lendy Chu, Max W Shen, May Sabry, Ive Logister, Richard I Sherwood, David K Gifford
Published 2021-03-01

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

by Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Published 2021-02-01