Suppression of cancer progression by MGAT1 shRNA knockdown.

Suppression of cancer progression by MGAT1 shRNA knockdown.

Oncogenic signaling promotes tumor invasion and metastasis, in part, by increasing the expression of tri- and tetra- branched N-glycans. The branched N-glycans bind to galectins forming a multivalent lattice that enhances cell surface residency of growth factor receptors, and focal adhesion turnover...

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Bibliographic Details
Main Authors: Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3434202?pdf=render

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http://europepmc.org/articles/PMC3434202?pdf=render

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