Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

In an analysis of amyloid pathology in Alzheimer disease, we used an in situ approach to identify amyloid-β (Aβ) accumulation and oxidative damage to nucleic acids in postmortem brain tissue of the hippocampal formation from subjects with Alzheimer disease. When carboxyl-terminal-specific antibodies...

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Bibliographic Details
Main Authors: Akihiko Nunomura, Toshio Tamaoki, Koich Tanaka, Nobutaka Motohashi, Masao Nakamura, Takaaki Hayashi, Haruyasu Yamaguchi, Shun Shimohama, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, George Perry
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
8-Hydroxyguanosine
Intraneuronal amyloid-β
Nucleic acids
Oligomer
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003672

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http://www.sciencedirect.com/science/article/pii/S0969996109003672

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