Toxin-Induced and Genetic Animal Models of Parkinson's Disease

by Shin Hisahara, Shun Shimohama
Published 2011-01-01

Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules

by Naoya Amimoto, Kaneyasu Nishimura, Shun Shimohama, Kazuyuki Takata
Published 2021-08-01

SIRT1 deficiency interferes with membrane resealing after cell membrane injury.

by Daisuke Fujiwara, Naotoshi Iwahara, Rio Sebori, Ryusuke Hosoda, Shun Shimohama, Atsushi Kuno, Yoshiyuki Horio
Published 2019-01-01

Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells

by Daiju Tsuchiya, Yoshihisa Kitamura, Kazuyuki Takata, Takashi Taniguchi, Kengo Uemura, Hiroaki Miki, Tadaomi Takenawa, Shun Shimohama
Published 2006-01-01

Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia

by Yoshihisa Kitamura, Daijiro Yanagisawa, Masatoshi Inden, Kazuyuki Takata, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi, Shun Shimohama
Published 2005-01-01

Proteasome Inhibitors Protect Against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats

by Masatoshi Inden, Jun-ichi Kondo, Yoshihisa Kitamura, Kazuyuki Takata, Kaneyasu Nishimura, Takashi Taniguchi, Hideyuki Sawada, Shun Shimohama
Published 2005-01-01

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ 12,14 Prostaglandin J2-Sensitive Microglial Activation

by Kazuyuki Takata, Yoshihisa Kitamura, Masaaki Umeki, Daiju Tsuchiya, Jun-ichi Kakimura, Takashi Taniguchi, Peter J. Gebicke-Haerter, Shun Shimohama
Published 2003-01-01

Involvement of Wiskott-Aldrich Syndrome Protein Family Verprolin- Homologous Protein (WAVE) and Rac1 in the Phagocytosis of Amyloid- β(1 – 42) in Rat Microglia

by Yoshihisa Kitamura, Keiichi Shibagaki, Kazuyuki Takata, Daiju Tsuchiya, Takashi Taniguchi, Peter J. Gebicke-Haerter, Hiroaki Miki, Tadaomi Takenawa, Shun Shimohama
Published 2003-01-01

Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model

by Yoshihisa Kitamura, Masatoshi Inden, Hisakazu Sanada, Kazuyuki Takata, Takashi Taniguchi, Shun Shimohama, Hidehumi Orii, Makoto Mochii, Kiyokazu Agata, Kenji Watanabe
Published 2003-01-01

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

by Kazuyuki Takata, Tetsuya Takada, Aina Ito, Mayo Asai, Manami Tawa, Yuki Saito, Eishi Ashihara, Hidekazu Tomimoto, Yoshihisa Kitamura, Shun Shimohama
Published 2012-01-01

Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons

by Masatoshi Inden, Dohoon Kim, Yuanjin Gu, Yoshihisa Kitamura, Jun-ichi Kondo, Daiju Tsuchiya, Takashi Taniguchi, Shun Shimohama, Akinori Akaike, Shoichiro Sumi, Kazutomo Inoue
Published 2004-01-01

Multiple system atrophy in Hokkaido, Japan: a prospective registry study of natural history and symptom assessment scales followed for 5 years

by Hidenao Sasaki, Asako Takei, Masaaki Matsushima, Ken Sakushima, Yasuhiro Kanatani, Naoki Nishimoto, Takeshi Matsuoka, Jun Sawada, Haruo Uesugi, Kazuya Sako, Shun Shimohama, Seiji Kikuchi
Published 2021-02-01

Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

by Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita
Published 2013-01-01

Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.

by Yoko Okamoto, Yoshitomo Shirakashi, Masafumi Ihara, Makoto Urushitani, Miki Oono, Yasuhiro Kawamoto, Hirofumi Yamashita, Shun Shimohama, Shinsuke Kato, Asao Hirano, Hidekazu Tomimoto, Hidefumi Ito, Ryosuke Takahashi
Published 2011-01-01

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

by Akihiko Nunomura, Toshio Tamaoki, Koich Tanaka, Nobutaka Motohashi, Masao Nakamura, Takaaki Hayashi, Haruyasu Yamaguchi, Shun Shimohama, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, George Perry
Published 2010-03-01

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

by Masato Maesako, Maiko Uemura, Yoshitaka Tashiro, Kazuki Sasaki, Kiwamu Watanabe, Yasuha Noda, Karin Ueda, Megumi Asada-Utsugi, Masakazu Kubota, Katsuya Okawa, Masafumi Ihara, Shun Shimohama, Kengo Uemura, Ayae Kinoshita
Published 2015-01-01

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

by Masatoshi Inden, Takahiro Taira, Yoshihisa Kitamura, Takashi Yanagida, Daiju Tsuchiya, Kazuyuki Takata, Daijiro Yanagisawa, Kaneyasu Nishimura, Takashi Taniguchi, Yoshiaki Kiso, Kanji Yoshimoto, Tomohiro Agatsuma, Shizuyo Koide-Yoshida, Sanae M.M. Iguchi-Ariga, Shun Shimohama, Hiroyoshi Ariga
Published 2006-10-01

HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data

by Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira
Published 2021-01-01