A genetically encoded FRET lactate sensor and its use to detect the Warburg effect in single cancer cells.

Lactate is shuttled between and inside cells, playing metabolic and signaling roles in healthy tissues. Lactate is also a harbinger of altered metabolism and participates in the pathogenesis of inflammation, hypoxia/ischemia, neurodegeneration and cancer. Many tumor cells show high rates of lactate...

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Bibliographic Details
Main Authors: Alejandro San Martín, Sebastián Ceballo, Iván Ruminot, Rodrigo Lerchundi, Wolf B Frommer, Luis Felipe Barros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3582500?pdf=render