Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg sup...

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Bibliographic Details
Main Authors: Marc Rosenbaum, Andreas Gewies, Konstanze Pechloff, Christoph Heuser, Thomas Engleitner, Torben Gehring, Lara Hartjes, Sabrina Krebs, Daniel Krappmann, Mark Kriegsmann, Wilko Weichert, Roland Rad, Christian Kurts, Jürgen Ruland
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10203-2

Internet

https://doi.org/10.1038/s41467-019-10203-2

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