CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis

by Lara Hartjes, Jürgen Ruland, Jürgen Ruland, Jürgen Ruland
Published 2019-03-01

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis

by Mariano Prado Acosta, Guillaume Goyette-Desjardins, Jörg Scheffel, Anne Dudeck, Jürgen Ruland, Jürgen Ruland, Jürgen Ruland, Bernd Lepenies
Published 2021-03-01

Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation

by Julian Hofmann, Julian Hofmann, Iana Gadjalova, Iana Gadjalova, Ritu Mishra, Ritu Mishra, Jürgen Ruland, Jürgen Ruland, Selina J. Keppler, Selina J. Keppler
Published 2021-01-01

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

by Tamás Németh, Krisztina Futosi, Cassian Sitaru, Jürgen Ruland, Attila Mócsai
Published 2016-04-01

The CARD9-Associated C-Type Lectin, Mincle, Recognizes La Crosse Virus (LACV) but Plays a Limited Role in Early Antiviral Responses against LACV

by João T. Monteiro, Kathleen Schön, Tim Ebbecke, Ralph Goethe, Jürgen Ruland, Wolfgang Baumgärtner, Stefanie C. Becker, Bernd Lepenies
Published 2019-03-01

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

by Anna Sledzińska, Saskia Hemmers, Florian Mair, Oliver Gorka, Jürgen Ruland, Lynsey Fairbairn, Anja Nissler, Werner Müller, Ari Waisman, Burkhard Becher, Thorsten Buch
Published 2013-10-01

Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination

by Rebecca Heß, Michael Storcksdieck genannt Bonsmann, Dennis Lapuente, Andre Maaske, Carsten Kirschning, Jürgen Ruland, Bernd Lepenies, Drew Hannaman, Matthias Tenbusch, Klaus Überla
Published 2019-02-01

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

by Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube
Published 2018-10-01

Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.

by Susanne Kratzat, Viktoriya Nikolova, Cornelius Miething, Alexander Hoellein, Stephanie Schoeffmann, Oliver Gorka, Elke Pietschmann, Anna-Lena Illert, Jürgen Ruland, Christian Peschel, Jonas Nilsson, Justus Duyster, Ulrich Keller
Published 2012-01-01

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

by Marc Rosenbaum, Andreas Gewies, Konstanze Pechloff, Christoph Heuser, Thomas Engleitner, Torben Gehring, Lara Hartjes, Sabrina Krebs, Daniel Krappmann, Mark Kriegsmann, Wilko Weichert, Roland Rad, Christian Kurts, Jürgen Ruland
Published 2019-05-01

The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development

by Marie-Kristin Raulf, Timo Johannssen, Svea Matthiesen, Konstantin Neumann, Severin Hachenberg, Sabine Mayer-Lambertz, Fridolin Steinbeis, Jan Hegermann, Peter H. Seeberger, Wolfgang Baumgärtner, Christina Strube, Jürgen Ruland, Bernd Lepenies
Published 2019-07-01

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

by Divya Sagar, Narendra P. Singh, Rashida Ginwala, Xiaofang Huang, Ramila Philip, Mitzi Nagarkatti, Prakash Nagarkatti, Konstantin Neumann, Jürgen Ruland, Allison M. Andrews, Servio H. Ramirez, Zafar K. Khan, Pooja Jain
Published 2017-06-01

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

by Andreas Gewies, Oliver Gorka, Hanna Bergmann, Konstanze Pechloff, Franziska Petermann, Katharina M. Jeltsch, Martina Rudelius, Mark Kriegsmann, Wilko Weichert, Marion Horsch, Johannes Beckers, Wolfgang Wurst, Mathias Heikenwalder, Thomas Korn, Vigo Heissmeyer, Jürgen Ruland
Published 2014-11-01

Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance

by Matthew Van Beek, Katherine I. Oravecz-Wilson, Phillip C. Delekta, Shufang Gu, Xiangquan Li, Xiaohong Jin, Ingrid J. Apel, Katy S. Konkle, Yongjia Feng, Daniel H. Teitelbaum, Jürgen Ruland, Linda M. McAllister-Lucas, Peter C. Lucas
Published 2012-05-01

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

by Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß
Published 2017-12-01

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

by Monica Yabal, Nicole Müller, Heiko Adler, Nathalie Knies, Christina J. Groß, Rune Busk Damgaard, Hirokazu Kanegane, Marc Ringelhan, Thomas Kaufmann, Mathias Heikenwälder, Andreas Strasser, Olaf Groß, Jürgen Ruland, Christian Peschel, Mads Gyrd-Hansen, Philipp J. Jost
Published 2014-06-01

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

by Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Published 2021-06-01

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

by Isabel Meininger, Richard A. Griesbach, Desheng Hu, Torben Gehring, Thomas Seeholzer, Arianna Bertossi, Jan Kranich, Andrea Oeckinghaus, Andrea C. Eitelhuber, Ute Greczmiel, Andreas Gewies, Marc Schmidt-Supprian, Jürgen Ruland, Thomas Brocker, Vigo Heissmeyer, Florian Heyd, Daniel Krappmann
Published 2016-04-01

IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells

by Serkan I. Göktuna, Ozge Canli, Julia Bollrath, Alexander A. Fingerle, David Horst, Michaela A. Diamanti, Charles Pallangyo, Moritz Bennecke, Tim Nebelsiek, Arun K. Mankan, Roland Lang, David Artis, Yinling Hu, Thomas Patzelt, Jürgen Ruland, Thomas Kirchner, M. Mark Taketo, Alain Chariot, Melek C. Arkan, Florian R. Greten
Published 2014-06-01

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients

by Sebastian Deschler, Juliane Kager, Johanna Erber, Lisa Fricke, Plamena Koyumdzhieva, Alexandra Georgieva, Tobias Lahmer, Johannes R. Wissner, Florian Voit, Jochen Schneider, Julia Horstmann, Roman Iakoubov, Matthias Treiber, Christof Winter, Jürgen Ruland, Dirk H. Busch, Percy A. Knolle, Ulrike Protzer, Christoph D. Spinner, Roland M. Schmid, Michael Quante, Katrin Böttcher
Published 2021-02-01