Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

The molecular chaperone heat shock protein 90 (Hsp90) is a current inhibition target for the treatment of diseases, including cancer. In humans, there are two major cytosolic isoforms of Hsp90 (Hsp90α and Hsp90β). Hsp90α is inducible and Hsp90β is constitutively e...

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Bibliographic Details
Main Authors: Oi Wei Mak, Raina Chand, Jóhannes Reynisson, Ivanhoe K. H. Leung
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
hsp90
virtual screening
intrinsic tryptophan fluorescence
ligand binding
isoform-selective
Online Access:https://www.mdpi.com/1422-0067/20/21/5333

Internet

https://www.mdpi.com/1422-0067/20/21/5333

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