Generation of Quality Hit Matter for Successful Drug Discovery Projects

by Jóhannes Reynisson
Published 2019-01-01

Advances in Anticancer Drug Discovery

by Jóhannes Reynisson
Published 2021-03-01

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

by Oi Wei Mak, Raina Chand, Jóhannes Reynisson, Ivanhoe K. H. Leung
Published 2019-10-01

Development of Thienopyridines as Potent Antiproliferative Agents

by David Barker, Lisa Ivy Pilkington, Natalie Haverkate, Euphemia Leung, Johannes Reynisson
Published 2019-08-01

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents

by Ayesha Zafar, Suat Sari, Euphemia Leung, Lisa I. Pilkington, Michelle van Rensburg, David Barker, Jóhannes Reynisson
Published 2017-12-01

Author Correction: Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment

by Sandra Marijan, Anita Markotić, Angela Mastelić, Nikolina Režić-Mužinić, Lisa Ivy Pilkington, Johannes Reynisson, Vedrana Čikeš Čulić
Published 2021-04-01

Thieno[2,3-<i>b</i>]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s⁺ Breast Cancer Cells

by Sandra Marijan, Angela Mastelić, Anita Markotić, Nikolina Režić-Mužinić, Nikolina Vučenović, David Barker, Lisa I. Pilkington, Jóhannes Reynisson, Vedrana Čikeš Čulić
Published 2021-06-01

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

by Ram Prasad Bhusal, Wanting Jiao, Brooke X. C. Kwai, Jóhannes Reynisson, Annabelle J. Collins, Jonathan Sperry, Ghader Bashiri, Ivanhoe K. H. Leung
Published 2019-10-01

Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs

by Konstantin Volcho, Alexandra Zakharenko, Olga Luzina, Tatyana Khomenko, Evgeniy Suslov, Oksana Salomatina, Olga Zakharova, Nikolai Li-Zhulanov, Jóhannes Reynisson, Olga Lavrik, Nariman Salakhutdinov
Published 2019-08-01

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

by Elizaveta D. Gladkova, Arina A. Chepanova, Ekaterina S. Ilina, Alexandra L. Zakharenko, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Olga I. Lavrik, Nariman F. Salakhutdinov
Published 2021-03-01

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents

by Ayesha Zafar, Lisa I. Pilkington, Natalie A. Haverkate, Michelle van Rensburg, Euphemia Leung, Sisira Kumara, William A. Denny, David Barker, Ali Alsuraifi, Clare Hoskins, Jóhannes Reynisson
Published 2018-01-01

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

by Nikolai S. Li-Zhulanov, Alexandra L. Zakharenko, Arina A. Chepanova, Jinal Patel, Ayesha Zafar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Jóhannes Reynisson, Ivanhoe K. H. Leung, Olga I. Lavrik
Published 2018-09-01

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

by Daniel M. Ayine-Tora, Robert Kingsford-Adaboh, William A. Asomaning, Jerry J.E.K. Harrison, Felix C. Mills-Robertson, Yahaya Bukari, Patrick O. Sakyi, Sylvester Kaminta, Jóhannes Reynisson
Published 2016-10-01

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

by Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2021-07-01

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

by Oksana V. Salomatina, Irina I. Popadyuk, Alexandra L. Zakharenko, Olga D. Zakharova, Dmitriy S. Fadeev, Nina I. Komarova, Jóhannes Reynisson, H. John Arabshahi, Raina Chand, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2018-03-01

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments

by Aldar A. Munkuev, Evgenii S. Mozhaitsev, Arina A. Chepanova, Evgeniy V. Suslov, Dina V. Korchagina, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2021-05-01

The First Berberine-based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

by Elizaveta D. Gladkova, Ivan V. Nechepurenko, Roman A. Bredikhin, Arina A. Chepanova, Alexandra L. Zakharenko, Olga A. Luzina, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Evgeniya M. Mamontova, Rashid O. Anarbaev, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2020-09-01

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

by Arina A. Chepanova, Evgenii S. Mozhaitsev, Aldar A. Munkuev, Evgeniy V. Suslov, Dina V. Korchagina, Olga D. Zakharova, Alexandra L. Zakharenko, Jinal Patel, Daniel M. Ayine-Tora, Jóhannes Reynisson, Ivanhoe K. H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2019-07-01

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

by Tatyana M. Khomenko, Alexandra L. Zakharenko, Arina A. Chepanova, Ekaterina S. Ilina, Olga D. Zakharova, Vasily I. Kaledin, Valeriy P. Nikolin, Nelly A. Popova, Dina V. Korchagina, Jóhannes Reynisson, Raina Chand, Daniel M. Ayine-Tora, Jinal Patel, Ivanhoe K. H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2019-12-01

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

by Aleksander S. Filimonov, Arina A. Chepanova, Olga A. Luzina, Alexandra L. Zakharenko, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Maxim S. Kuprushkin, Anton V. Kolotaev, Derenik S. Khachatryan, Jinal Patel, Ivanhoe K.H. Leung, Raina Chand, Daniel M. Ayine-Tora, Johannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2019-10-01